Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003265.3

p.L412P

c.1235T>C

Surrounding Variants

5 papers

NM_003265.3

p.L412V

c.1234C>G

206 papers

NM_003265.3

p.L412F

c.1234C>T

2 papers

NM_003265.3

p.L412L

c.1236C>T

1 paper

NM_003265.3

p.N413D

c.1237A>G

1 paper

NM_003265.3

p.S420_A426del7

c.1258_1277del21

1 paper

NM_003265.3

p.K421E

c.1261A>G

1 paper

NM_003265.3

p.K421*

c.1261A>T

1 paper

NM_003265.3

p.I422T

c.1265T>C

1 paper

NM_003265.3

p.E399_T400delins

c.1196_1198delinsTTT

2 papers

NM_003265.3

p.R394Q

c.1181G>A

2 papers

NM_003265.3

p.R394*

c.1180C>T

2 papers

NM_003265.3

p.H432R

c.1295A>G