Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.K745E

c.2233A>G

Surrounding Variants

14 papers

NM_003265.3

p.E746*

c.2236G>T

12 papers

NM_003265.3

p.G743D

c.2228G>A

4 papers

NM_003265.3

p.L742F

c.2224C>T

1 paper

NM_003265.3

p.R740Q

c.2219G>A

2 papers

NM_003265.3

p.T751fs

c.2251_2252fs

1 paper

NM_003265.3

p.T751fs

c.2251_2252fs

1 paper

NM_003265.3

p.T751R

c.2252C>G

1 paper

NM_003265.3

p.V738I

c.2212G>A

1 paper

NM_003265.3

p.S737*

c.2210C>A

1 paper

NM_003265.3

p.S737*

c.2210C>G

1 paper

NM_003265.3

p.Q753*

c.2257C>T

9 papers

NM_003265.3

p.S737T

c.2209T>A