Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1465 papers

NM_138554.5

p.D299G

c.896A>G

NM_003266.4

p.D259G

c.776A>G

Surrounding Variants

2 papers

NM_138554.5

p.D299A

c.896A>C

2 papers

NM_138554.5

p.D299V

c.896A>T

2 papers

NM_138554.5

p.D299N

c.895G>A

2 papers

NM_138554.5

p.D299E

c.897T>A

2 papers

NM_138554.5

p.D299E

c.897T>G

4 papers

NM_138554.5

p.D298G

c.893A>G

2 papers

NM_138554.5

p.D298N

c.892G>A

1 paper

NM_138554.5

p.D298H

c.892G>C

1 paper

NM_138554.5

p.I300M

c.900T>G

2 papers

NM_138554.5

p.I301T

c.902T>C

2 papers

NM_138554.5

p.L297F

c.889C>T

1 paper

NM_138554.5

p.Y296C

c.887A>G