Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.T399S

c.1196C>G

Surrounding Variants

1036 papers

NM_138554.5

p.T399I

c.1196C>T

NM_003266.4

p.T359I

c.1076C>T

1 paper

NM_138554.5

p.T399A

c.1195A>G

4 papers

NM_138554.5

p.T398T

c.1194A>G

3 papers

NM_138554.5

p.S400N

c.1199G>A

1 paper

NM_138554.5

p.L401L

c.1201C>T

2 papers

NM_003266.4

p.K362E

c.1084A>G

NM_138554.5

p.K402E

c.1204A>G

1 paper

NM_138554.5

p.D395Y

c.1183G>T

1 paper

NM_138554.5

p.S394G

c.1180A>G

1 paper

NM_138554.5

p.S394C

c.1180A>T

1 paper

NM_138554.5

p.D405N

c.1213G>A

1 paper

NM_138554.5

p.L406_S407insFs

c.1218_1219insA

1 paper

NM_138554.5

p.S407R

c.1221C>G