Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.V222D

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
9 papers
NM_016562.4
p.V222D
c.665T>A
Surrounding Variants
1 paper
NM_016562.4
p.V222L
c.664G>C
2 papers
NM_016562.4
p.T221del1
c.661_662delACT
7 papers
NM_016562.4
p.V219I
c.655G>A
1 paper
NM_016562.4
p.T226I
c.677C>T
1 paper
NM_016562.4
p.L227delFs
c.680delT
4 papers
NM_016562.4
p.L227fs
c.679_680fs
5 papers
NM_016562.4
p.N215S
c.644A>G
1 paper
NM_016562.4
p.L209P
c.626T>C
1 paper
NM_016562.4
p.A238E
c.713C>A
1 paper
NM_016562.4
p.E242del1
c.724_725delGAA
1 paper
NM_016562.4
p.D243E
c.729T>A
1 paper
NM_016562.4
p.D243E
c.729T>G
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