Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.N275K

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.N275K
c.825T>A
Surrounding Variants
1 paper
NM_016562.4
p.N275K
c.825T>G
1 paper
NM_016562.4
p.N275T
c.824A>C
1 paper
NM_016562.4
p.K274E
c.820A>G
6 papers
NM_016562.4
p.P267L
c.800C>T
1 paper
NM_016562.4
p.N284I
c.851A>T
1 paper
NM_016562.4
p.N265K
c.795T>A
1 paper
NM_016562.4
p.N265K
c.795T>G
21 papers
NM_016562.4
p.Y264H
c.790T>C
1 paper
NM_016562.4
p.A288E
c.863C>A
8 papers
NM_016562.4
p.A288V
c.863C>T
1 paper
NM_016562.4
p.L295F
c.885A>T
2 papers
NM_016562.4
p.R296C
c.886C>T
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."