Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.V459V

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_016562.4
p.V459V
c.1377C>T
Surrounding Variants
1 paper
NM_016562.4
p.Q462_L463insFs
c.1386_1389dup4
2 papers
NM_016562.4
p.H464fs
c.1390_1391fs
1 paper
NM_016562.4
p.Y468H
c.1402T>C
1 paper
NM_016562.4
p.Y468*
c.1404T>A
3 papers
NM_016562.4
p.T450T
c.1350T>C
1 paper
NM_016562.4
p.Y468*
c.1404T>G
1 paper
NM_016562.4
p.A448A
c.1344C>T
20 papers
NM_016562.4
p.A448V
c.1343C>T
1 paper
NM_016562.4
p.R473K
c.1418G>A
1 paper
NM_016562.4
p.K478E
c.1432A>G
1 paper
NM_016562.4
p.K432R
c.1295A>G
1 paper
NM_016562.4
p.Q496*
c.1486C>T
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