Varaico: Literature-Extracted Genetic Variants

Gene:TLR7
Variant:p.G816R

TLR7

384 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 496–554UCSCLeucine rich repeat
LRR_1aa 700–721UCSCLeucine Rich Repeat
TIRaa 890–1044UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 7

HGNC Previous Name

toll-like receptor 7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_016562.4
p.G816R
c.2446G>A
Surrounding Variants
3 papers
NM_016562.4
p.G818V
c.2453G>T
1 paper
NM_016562.4
p.A819T
c.2455G>A
1 paper
NM_016562.4
p.V825E
c.2474T>A
6 papers
NM_016562.4
p.T801T
c.2403G>A
14 papers
NM_016562.4
p.V795F
c.2383G>T
1 paper
NM_016562.4
p.L840R
c.2519T>G
1 paper
NM_016562.4
p.L842L
c.2524C>T
1 paper
NM_016562.4
p.R784R
c.2352G>A
1 paper
NM_016562.4
p.H782D
c.2344C>G
4 papers
NM_016562.4
p.H781L
c.2342A>T
4 papers
NM_016562.4
p.M854I
c.2562G>A
4 papers
NM_016562.4
p.M854I
c.2562G>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."