Varaico: Literature-Extracted Genetic Variants

TNK2

162 papers

RefSeq Summary

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is ...

Pfam Domains

SAM_TNKaa 10–65UCSCSAM domain-like

PK_Tyr_Ser-Thraa 126–385UCSCProtein tyrosine and serine/threonine kinase

SH3_9aa 395–444UCSCVariant SH3 domain

GTPase_bindingaa 449–514UCSCGTPase binding

Inhibitor_Mig-6aa 774–840UCSCEGFR receptor inhibitor Mig-6

Gene Aliases

HGNC Name

tyrosine kinase non receptor 2

HGNC Alias Symbols

p21cdc42Hs; ACK; ACK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_001382273.1

p.K158R

c.473A>G

Surrounding Variants

1 paper

NM_001382273.1

p.V157L

c.469G>T

1 paper

NM_001382273.1

p.V157L

c.469G>C

1 paper

NM_001382273.1

p.V157M

c.469G>A

3 papers

NM_001382273.1

p.A156T

c.466G>A

1 paper

NM_001382273.1

p.L160L

c.480G>A

3 papers

NM_001382273.1

p.K161Q

c.481A>C

1 paper

NM_001382273.1

p.V155L

c.463G>T

1 paper

NM_001382273.1

p.V155L

c.463G>C

2 papers

NM_001382273.1

p.P162S

c.484C>T

1 paper

NM_001382273.1

p.P162P

c.486C>T

2 papers

NM_001382273.1

p.D163E

c.489T>G

2 papers

NM_001382273.1

p.D163E

c.489T>A