Varaico: Literature-Extracted Genetic Variants

TOP2A

335 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 78–224UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 266–430UCSCDNA gyrase B

Toprimaa 456–574UCSCToprim domain

TOPRIM_Caa 573–711UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 713–1172UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1430–1522UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II alpha

HGNC Previous Symbol

TOP2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001067.4

p.S802R

c.2406T>G

Surrounding Variants

1 paper

NM_001067.4

p.S802R

c.2406T>A

1 paper

NM_001067.4

p.P803S

c.2407C>T

1 paper

NM_001067.4

p.S802R

c.2404A>C

1 paper

NM_001067.4

p.S800A

c.2398T>G

3 papers

NM_001067.4

p.Y805F

c.2414A>T

1 paper

NM_001067.4

p.Y805S

c.2414A>C

1 paper

NM_001067.4

p.F807L

c.2419T>C

1 paper

NM_001067.4

p.F807L

c.2421T>G

1 paper

NM_001067.4

p.F807L

c.2421T>A

1 paper

NM_001067.4

p.T808K

c.2423C>A

1 paper

NM_001067.4

p.T792P

c.2374A>C

2 papers

NM_001067.4

p.Q789*

c.2365C>T