Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001126118.2

p.K342K

c.1026A>G

Surrounding Variants

7 papers

NM_000546.6

p.K381N

c.1143A>T

6 papers

NM_000546.6

p.K381N

c.1143A>C

4 papers

NM_000546.6

p.K381I

c.1142A>T

1 paper

NM_000546.6

p.K382*

c.1144A>T

16 papers

NM_000546.6

p.K381R

c.1142A>G

NM_001126118.2

p.K342R

c.1025A>G

4 papers

NM_000546.6

p.K382E

c.1144A>G

16 papers

NM_000546.6

p.K382Q

c.1144A>C

5 papers

NM_000546.6

p.K381T

c.1142A>C

NM_001126118.2

p.K342T

c.1025A>C

1 paper

NM_000546.6

p.K382_L383insT

c.1144_1148ins3

1 paper

NM_000546.6

p.K382_L383ins12

c.1144_1148ins36

1 paper

NM_000546.6

p.H380_K381insFs

c.1139_1142dup4

20 papers

NM_000546.6

p.K382fs

c.1144_1145fs