Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.R379S

c.1135C>A

Surrounding Variants

19 papers

NM_000546.6

p.R379C

c.1135C>T

NM_001126115.2

p.R247C

c.739C>T

1 paper

NM_000546.6

p.R379G

c.1135C>G

1 paper

NM_000546.6

p.R379_H380insG

c.1135_1139ins3

7 papers

NM_000546.6

p.R379insFs

c.1135_1136insA

3 papers

NM_000546.6

p.R379fs

c.1135_1136fs

1 paper

NM_000546.6

p.S378del1

c.1132_1133delGGA

2 papers

NM_000546.6

p.T377_S378del2

c.1129_1133del6

11 papers

NM_000546.6

p.R379L

c.1136G>T

1 paper

NM_001126115.2

p.R247P

c.740G>C

25 papers

NM_000546.6

p.R379H

c.1136G>A

NM_001126115.2

p.R247H

c.740G>A

1 paper

NM_000546.6

p.S378delFs

c.1133delG

2 papers

NM_000546.6

p.S378S

c.1134C>T