Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T377fs

c.1129_1130fs

Surrounding Variants

5 papers

NM_000546.6

p.T377S

c.1129A>T

7 papers

NM_000546.6

p.T377A

c.1129A>G

22 papers

NM_000546.6

p.T377P

c.1129A>C

NM_001126115.2

p.T245P

c.733A>C

1 paper

NM_000546.6

p.T377insFs

c.1129_1130insT

2 papers

NM_000546.6

p.T377_S378insT

c.1129_1133ins3

1 paper

NM_000546.6

p.T377insFs

c.1129_1130ins5

1 paper

NM_000546.6

p.Q375_S376delFs

c.1125_1128del4

1 paper

NM_000546.6

p.S376_T377insFs

c.1128_1129insG

1 paper

NM_000546.6

p.S376_T377insFs

c.1128_1129insC

1 paper

NM_000546.6

p.S376fs

c.1126_1127fs

1 paper

NM_000546.6

p.S376_T377insFs

c.1128_1129insA

1 paper

NM_000546.6

p.S376_T377insFs

c.1128_1129insAA