Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.S376T

c.1126T>A

Surrounding Variants

1 paper

NM_000546.6

p.S376_T377insC

c.1126_1130ins3

1 paper

NM_000546.6

p.S376insFs

c.1126_1127insA

13 papers

NM_000546.6

p.S376A

c.1126T>G

3 papers

NM_000546.6

p.S376P

c.1126T>C

2 papers

NM_000546.6

p.Q375delFs

c.1125delC

1 paper

NM_000546.6

p.Q375del1

c.1123_1124delCTG

1 paper

NM_000546.6

p.G374_Q375del2

c.1120_1124del6

1 paper

NM_000546.6

p.K372_Q375delFs

c.1115_1125del11

1 paper

NM_000546.6

p.K372_Q375del4

c.1114_1124del12

4 papers

NM_000546.6

p.S376fs

c.1126_1127fs

3 papers

NM_000546.6

p.Q375H

c.1125G>T

4 papers

NM_000546.6

p.Q375fs

c.1123_1124fs