Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.K370*

c.1108A>T

Surrounding Variants

4 papers

NM_000546.6

p.K370E

c.1108A>G

9 papers

NM_000546.6

p.K370Q

c.1108A>C

2 papers

NM_000546.6

p.K370_S371insG

c.1108_1112ins3

1 paper

NM_000546.6

p.K370_S371ins6

c.1108_1112ins18

1 paper

NM_000546.6

p.K370_S371ins10

c.1108_1112ins30

2 papers

NM_000546.6

p.L369fs

c.1105_1106fs

1 paper

NM_000546.6

p.L369L

c.1107G>A

2 papers

NM_000546.6

p.K370M

c.1109A>T

22 papers

NM_000546.6

p.K370R

c.1109A>G

4 papers

NM_000546.6

p.K370T

c.1109A>C

1 paper

NM_000546.6

p.K370insFs

c.1109_1110insC

1 paper

NM_000546.6

p.L369R

c.1106T>G