Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.K357*

c.1069A>T

Surrounding Variants

2 papers

NM_000546.6

p.K357fs

c.1069_1070fs

6 papers

NM_000546.6

p.K357E

c.1069A>G

5 papers

NM_000546.6

p.K357Q

c.1069A>C

1 paper

NM_000546.6

p.K357_E358insC

c.1069_1073ins3

2 papers

NM_000546.6

p.G356delFs

c.1066delC

1 paper

NM_000546.6

p.G356delFs

c.1066_1067delCC

2 papers

NM_001126115.2

p.G224G

c.672G>T

NM_000546.6

p.G356G

c.1068G>T

2 papers

NM_001126115.2

p.G224G

c.672G>A

NM_000546.6

p.G356G

c.1068G>A

1 paper

NM_000546.6

p.E349_G356delFs

c.1046_1067del22

4 papers

NM_000546.6

p.K357M

c.1070A>T

10 papers

NM_000546.6

p.K357R

c.1070A>G

3 papers

NM_000546.6

p.K357T

c.1070A>C