Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

33 papers

NM_000546.6

p.Q331R

c.992A>G

Surrounding Variants

5 papers

NM_000546.6

p.Q331L

c.992A>T

9 papers

NM_000546.6

p.Q331P

c.992A>C

1 paper

NM_000546.6

p.Q331insFs

c.992_993insT

9 papers

NM_000546.6

p.Q331delFs

c.991delG

1 paper

NM_000546.6

p.L330_Q331del1

c.989_991delGAA

1 paper

NM_000546.6

p.G325_Q331delFs

c.973_991del19

1 paper

NM_000546.6

p.P322_L330del9

c.964_989del27

69 papers

NM_000546.6

p.Q331H

c.993G>T

13 papers

NM_000546.6

p.Q331fs

c.991_992fs

67 papers

NM_000546.6

p.Q331H

c.993G>C

24 papers

NM_000546.6

p.Q331Q

c.993G>A

1 paper

NM_000546.6

p.Q331delFs

c.991_992delTG