Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S315_P316insC

c.943_947ins3

Surrounding Variants

1 paper

NM_000546.6

p.T312_S314insFs

c.936_942dup7

34 papers

NM_000546.6

p.S315A

c.943T>G

5 papers

NM_000546.6

p.S315P

c.943T>C

14 papers

NM_000546.6

p.S315T

c.943T>A

1 paper

NM_000546.6

p.S314delFs

c.942delG

13 papers

NM_000546.6

p.S315fs

c.943_944fs

1 paper

NM_000546.6

p.P309_S314delFs

c.925_941del17

8 papers

NM_000546.6

p.S315F

c.944C>T

2 papers

NM_000546.6

p.S314S

c.942C>T

5 papers

NM_000546.6

p.S315C

c.944C>G

2 papers

NM_000546.6

p.S314S

c.942C>G

6 papers

NM_000546.6

p.S314fs

c.940_941fs