Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G302_K305delFs

c.905_915del11

Surrounding Variants

617 papers

NM_000546.6

p.R306*

c.916C>T

NM_001126118.2

p.R267*

c.799C>T

1 paper

NM_000546.6

p.R306G

c.916C>G

1 paper

NM_000546.6

p.K305insFs

c.915dupG

2 papers

NM_000546.6

p.R306insFs

c.916_917ins4

1 paper

NM_000546.6

p.R306insFs

c.916_917insA

2 papers

NM_000546.6

p.R306R

c.916C>A

3 papers

NM_000546.6

p.K305delFs

c.915delC

10 papers

NM_000546.6

p.R306fs

c.916_917fs

18 papers

NM_000546.6

p.K305N

c.915G>T

3 papers

NM_000546.6

p.R306L

c.917G>T

1 paper

NM_000546.6

p.K305_R306insFs

c.915_916insT

1 paper

NM_000546.6

p.K305_R306insFs

c.915_916ins4