Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.T304I

c.911C>T

Surrounding Variants

3 papers

NM_000546.6

p.T304S

c.911C>G

3 papers

NM_000546.6

p.T304N

c.911C>A

2 papers

NM_000546.6

p.E298_T304insFs

c.892_911dup20

2 papers

NM_000546.6

p.T304fs

c.910_911fs

2 papers

NM_000546.6

p.T304T

c.912T>C

1 paper

NM_000546.6

p.T304delFs

c.911delG

8 papers

NM_000546.6

p.T304fs

c.910_911fs

1 paper

NM_000546.6

p.P301_T304delFs

c.902_911del10

3 papers

NM_000546.6

p.T304S

c.910A>T

15 papers

NM_000546.6

p.T304A

c.910A>G

3 papers

NM_000546.6

p.T304P

c.910A>C

3 papers

NM_000546.6

p.L299_S303delFs

c.896_909del14