Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.P301R

c.902C>G

Surrounding Variants

17 papers

NM_000546.6

p.P301L

c.902C>T

1 paper

NM_000546.6

p.P301insFs

c.902_903insG

1 paper

NM_000546.6

p.P301insFs

c.902_903ins1

7 papers

NM_000546.6

p.P301Q

c.902C>A

1 paper

NM_001126115.2

p.P169delins

c.505_506delinsTA

1 paper

NM_000546.6

p.P295_P301delFs

c.885_901del17

15 papers

NM_000546.6

p.P301S

c.901C>T

4 papers

NM_000546.6

p.P301A

c.901C>G

2 papers

NM_000546.6

p.P301insFs

c.901_902insT

5 papers

NM_000546.6

p.P301T

c.901C>A

1 paper

NM_000546.6

p.P301P

c.903A>T

5 papers

NM_000546.6

p.P301P

c.903A>G