Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.P301T

c.901C>A

Surrounding Variants

15 papers

NM_000546.6

p.P301S

c.901C>T

4 papers

NM_000546.6

p.P301A

c.901C>G

2 papers

NM_000546.6

p.P301insFs

c.901_902insT

35 papers

NM_000546.6

p.P301fs

c.901_902fs

17 papers

NM_000546.6

p.P301L

c.902C>T

2 papers

NM_000546.6

p.P300P

c.900C>T

4 papers

NM_000546.6

p.P301R

c.902C>G

2 papers

NM_000546.6

p.P300P

c.900C>G

1 paper

NM_000546.6

p.P300_P301insFs

c.900_901insT

1 paper

NM_000546.6

p.P301insFs

c.902_903insG

1 paper

NM_000546.6

p.L299_P300insFs

c.896_899dup4

2 papers

NM_000546.6

p.P300fs

c.898_899fs