Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

41 papers

NM_000546.6

p.T284P

c.850A>C

Surrounding Variants

18 papers

NM_000546.6

p.T284S

c.850A>T

10 papers

NM_000546.6

p.T284A

c.850A>G

2 papers

NM_000546.6

p.T284_E285insG

c.850_854ins3

1 paper

NM_000546.6

p.T284_E285insLP

c.850_854ins6

1 paper

NM_000546.6

p.R283delFs

c.849delG

4 papers

NM_000546.6

p.R283delFs

c.848_849delGC

2 papers

NM_000546.6

p.R282_R283del0

c.844_849del6

1 paper

NM_000546.6

p.E271_R283del13

c.811_848del39

12 papers

NM_000546.6

p.T284fs

c.850_851fs

16 papers

NM_001126118.2

p.T245I

c.734C>T

NM_000546.6

p.T284I

c.851C>T

2 papers

NM_000546.6

p.R283R

c.849C>T

13 papers

NM_000546.6

p.T284R

c.851C>G

NM_001276698.3

p.T125R

c.374C>G