Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.R267insFs

c.801dupG

Surrounding Variants

16 papers

NM_000546.6

p.N268fs

c.802_803fs

7 papers

NM_000546.6

p.N268Y

c.802A>T

98 papers

NM_000546.6

p.N268D

c.802A>G

5 papers

NM_000546.6

p.N268H

c.802A>C

1 paper

NM_000546.6

p.N268insFs

c.802_803insCT

1 paper

NM_000546.6

p.N268_S269insG

c.802_806ins3

1 paper

NM_000546.6

p.R267_N268delins

c.801_802delinsTT

18 papers

NM_000546.6

p.R267delFs

c.800delC

2 papers

NM_000546.6

p.G266_R267del2

c.796_800del6

1 paper

NM_000546.6

p.G262_R267del0

c.784_801del18

1 paper

NM_000546.6

p.R267R

c.801G>T

1 paper

NM_000546.6

p.R267_N268insFs

c.801_802insT