Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.L265M

c.793C>A

Surrounding Variants

9 papers

NM_000546.6

p.L265fs

c.793_794fs

4 papers

NM_000546.6

p.L265L

c.793C>T

4 papers

NM_000546.6

p.L265V

c.793C>G

1 paper

NM_000546.6

p.L265insFs

c.793_794insG

1 paper

NM_000546.6

p.L264insFs

c.792dupA

2 papers

NM_000546.6

p.N263_L264delFs

c.788_792del5

1 paper

NM_000546.6

p.N263_L264del0

c.787_792del6

1 paper

NM_000546.6

p.G262_L264delFs

c.785_792del8

44 papers

NM_000546.6

p.L265R

c.794T>G

130 papers

NM_000546.6

p.L265P

c.794T>C

14 papers

NM_000546.6

p.L265Q

c.794T>A

1 paper

NM_000546.6

p.L265delFs

c.793delG