Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.G245del1

c.733_735delGCC

Surrounding Variants

1 paper

NM_000546.6

p.M246fs

c.736_737fs

42 papers

NM_000546.6

p.M246L

c.736A>T

245 papers

NM_000546.6

p.M246V

c.736A>G

41 papers

NM_000546.6

p.M246L

c.736A>C

1 paper

NM_000546.6

p.G245insFs

c.735dupC

1 paper

NM_000546.6

p.G244_G245ins0

c.730_735dup6

1 paper

NM_000546.6

p.G245delFs

c.735delG

1 paper

NM_000546.6

p.G245_M246delins

c.733_736delinsTGCC

70 papers

NM_000546.6

p.M246R

c.737T>G

63 papers

NM_000546.6

p.M246T

c.737T>C

45 papers

NM_000546.6

p.M246K

c.737T>A

3 papers

NM_000546.6

p.M246delFs

c.736delT