Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.H233D

c.697C>G

Surrounding Variants

31 papers

NM_000546.6

p.H233Y

c.697C>T

1 paper

NM_000546.6

p.H233insFs

c.697_698insG

1 paper

NM_000546.6

p.H233_Y234insT

c.697_701ins3

10 papers

NM_000546.6

p.H233N

c.697C>A

1 paper

NM_000546.6

p.I232_H233delins

c.696_697delinsAG

1 paper

NM_000546.6

p.I232del1

c.694_695delGAT

2 papers

NM_000546.6

p.C229_I232del0

c.685_696del12

9 papers

NM_000546.6

p.H233fs

c.697_698fs

3 papers

NM_000546.6

p.I232I

c.696C>T

7 papers

NM_000546.6

p.I232M

c.696C>G

2 papers

NM_000546.6

p.I232insFs

c.695_696insT

8 papers

NM_000546.6

p.I232fs

c.694_695fs