Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V217_P222delFs

c.651_666del16

Surrounding Variants

8 papers

NM_000546.6

p.P223fs

c.667_668fs

20 papers

NM_000546.6

p.P223S

c.667C>T

7 papers

NM_000546.6

p.P223A

c.667C>G

1 paper

NM_000546.6

p.P223_E224insA

c.667_671ins3

5 papers

NM_000546.6

p.P223T

c.667C>A

1 paper

NM_000546.6

p.E221_P222delFs

c.662_666del5

5 papers

NM_000546.6

p.P222P

c.666G>T

1 paper

NM_000546.6

p.P222insFs

c.665dupC

4 papers

NM_000546.6

p.P222fs

c.664_665fs

2 papers

NM_000546.6

p.P222P

c.666G>C

12 papers

NM_000546.6

p.P222P

c.666G>A

5 papers

NM_000546.6

p.P222delFs

c.665delG