Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.F212L

c.634T>C

Surrounding Variants

1 paper

NM_000546.6

p.F212_R213ins7

c.634_638ins21

18 papers

NM_000546.6

p.F212V

c.634T>G

17 papers

NM_000546.6

p.F212I

c.634T>A

17 papers

NM_000546.6

p.F212fs

c.634_635fs

2 papers

NM_000546.6

p.T211delFs

c.632_633delAG

19 papers

NM_000546.6

p.T211fs

c.631_632fs

5 papers

NM_000546.6

p.T211T

c.633T>G

4 papers

NM_000546.6

p.F212C

c.635T>G

11 papers

NM_000546.6

p.F212S

c.635T>C

2 papers

NM_000546.6

p.T211T

c.633T>C

7 papers

NM_000546.6

p.F212Y

c.635T>A

2 papers

NM_000546.6

p.R209_F212delFs

c.625_634del10