Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.T211delFs

c.631delT

Surrounding Variants

98 papers

NM_000546.6

p.T211I

c.632C>T

9 papers

NM_000546.6

p.T211S

c.632C>G

1 paper

NM_000546.6

p.T211insFs

c.632_633insT

3 papers

NM_000546.6

p.T211insFs

c.631dupA

8 papers

NM_000546.6

p.T211N

c.632C>A

19 papers

NM_000546.6

p.T211fs

c.631_632fs

5 papers

NM_000546.6

p.T211T

c.633T>G

2 papers

NM_000546.6

p.T211T

c.633T>C

2 papers

NM_000546.6

p.T211delFs

c.632delG

11 papers

NM_000546.6

p.T211delFs

c.631_632delGT

12 papers

NM_000546.6

p.T211fs

c.631_632fs

1 paper

NM_000546.6

p.D207_T211delFs

c.619_632del14