Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.N210delFs

c.630delG

Surrounding Variants

12 papers

NM_000546.6

p.T211fs

c.631_632fs

9 papers

NM_000546.6

p.T211S

c.631A>T

33 papers

NM_000546.6

p.T211A

c.631A>G

22 papers

NM_000546.6

p.T211P

c.631A>C

1 paper

NM_000546.6

p.T211ins1

c.631_632insGCG

1 paper

NM_000546.6

p.T211_F212insGA

c.631_635ins6

1 paper

NM_000546.6

p.L206_N210del5

c.616_629del15

98 papers

NM_000546.6

p.T211I

c.632C>T

3 papers

NM_000546.6

p.N210N

c.630C>T

9 papers

NM_000546.6

p.T211S

c.632C>G

5 papers

NM_000546.6

p.N210K

c.630C>G

1 paper

NM_000546.6

p.T211insFs

c.632_633insT