Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V203_R209delFs

c.609_627del19

Surrounding Variants

13 papers

NM_000546.6

p.N210fs

c.628_629fs

11 papers

NM_000546.6

p.N210Y

c.628A>T

9 papers

NM_000546.6

p.N210D

c.628A>G

5 papers

NM_000546.6

p.N210H

c.628A>C

3 papers

NM_000546.6

p.N210_T211insG

c.628_632ins3

1 paper

NM_000546.6

p.R209insFs

c.626_627dupGA

1 paper

NM_000546.6

p.R209_N210delins

c.627_628delinsGG

126 papers

NM_000546.6

p.R209delFs

c.626_627delTC

1 paper

NM_000546.6

p.D208_R209delFs

c.624_627del4

1 paper

NM_000546.6

p.L206_R209delFs

c.618_627del10

1 paper

NM_000546.6

p.E204_R209delFs

c.612_627del16

8 papers

NM_000546.6

p.R209S

c.627A>T