Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R209insFs

c.626dupG

Surrounding Variants

8 papers

NM_000546.6

p.R209S

c.627A>T

7 papers

NM_000546.6

p.R209S

c.627A>C

104 papers

NM_000546.6

p.R209fs

c.625_626fs

3 papers

NM_000546.6

p.R209delFs

c.626delC

1 paper

NM_000546.6

p.V203_R209delFs

c.608_626del19

1 paper

NM_000546.6

p.E198_R209delFs

c.592_626del35

14 papers

NM_000546.6

p.R209I

c.626G>T

1 paper

NM_000546.6

p.R209insFs

c.625_626insAA

12 papers

NM_000546.6

p.R209T

c.626G>C

47 papers

NM_000546.6

p.R209K

c.626G>A

3 papers

NM_000546.6

p.R209delFs

c.625delT

1 paper

NM_000546.6

p.Y205_D208delFs

c.614_624del11