Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.E198V

c.593A>T

Surrounding Variants

12 papers

NM_000546.6

p.E198G

c.593A>G

3 papers

NM_000546.6

p.E198A

c.593A>C

1 paper

NM_000546.6

p.E198insFs

c.592dupG

10 papers

NM_000546.6

p.E198delFs

c.592delC

1 paper

NM_000546.6

p.V197del1

c.589_591delCAC

1 paper

NM_000546.6

p.H193_E198delFs

c.577_592del16

1 paper

NM_000546.6

p.A189_V197del0

c.565_591del27

112 papers

NM_000546.6

p.E198*

c.592G>T

2 papers

NM_000546.6

p.R196_V197insFs

c.588_591dup4

1 paper

NM_000546.6

p.E198_G199insC

c.592_596ins3

8 papers

NM_000546.6

p.E198Q

c.592G>C

23 papers

NM_000546.6

p.E198K

c.592G>A