Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.R196_V197insFs

c.588_591dup4

Surrounding Variants

112 papers

NM_000546.6

p.E198*

c.592G>T

1 paper

NM_000546.6

p.E198_G199insC

c.592_596ins3

8 papers

NM_000546.6

p.E198Q

c.592G>C

23 papers

NM_000546.6

p.E198K

c.592G>A

14 papers

NM_000546.6

p.E198fs

c.592_593fs

1 paper

NM_000546.6

p.V197insFs

c.590dupT

1 paper

NM_000546.6

p.I195_V197ins1

c.584_589dup6

2 papers

NM_000546.6

p.V197fs

c.589_590fs

4 papers

NM_000546.6

p.V197V

c.591G>A

2 papers

NM_000546.6

p.V197delFs

c.590delA

1 paper

NM_000546.6

p.I195_V197del0

c.584_589del6

6 papers

NM_000546.6

p.E198V

c.593A>T