Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.I195L

c.583A>C

Surrounding Variants

14 papers

NM_000546.6

p.I195fs

c.583_584fs

126 papers

NM_000546.6

p.I195F

c.583A>T

5 papers

NM_000546.6

p.I195V

c.583A>G

6 papers

NM_000546.6

p.L194_I195insFs

c.582_583insT

1 paper

NM_000546.6

p.I195_R196insT

c.583_587ins3

1 paper

NM_000546.6

p.I195_R196ins4

c.583_587ins12

6 papers

NM_000546.6

p.L194delFs

c.582delA

3 papers

NM_000546.6

p.L194del1

c.580_582delAAG

1 paper

NM_000546.6

p.Q192_L194del3

c.574_581del9

1 paper

NM_000546.6

p.P191_L194delFs

c.572_582del11

1 paper

NM_000546.6

p.A189_L194delFs

c.566_582del17

1 paper

NM_000546.6

p.I195ins2

c.584_585ins6