Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.P190A

c.568C>G

Surrounding Variants

16 papers

NM_000546.6

p.P190fs

c.568_569fs

40 papers

NM_000546.6

p.P190S

c.568C>T

NM_001126118.2

p.P151S

c.451C>T

43 papers

NM_000546.6

p.P190T

c.568C>A

188 papers

NM_000546.6

p.P190L

c.569C>T

2 papers

NM_000546.6

p.A189A

c.567C>T

38 papers

NM_000546.6

p.P190R

c.569C>G

NM_001126115.2

p.P58R

c.173C>G

NM_001126118.2

p.P151R

c.452C>G

5 papers

NM_000546.6

p.A189fs

c.565_566fs

6 papers

NM_000546.6

p.P190H

c.569C>A

1 paper

NM_000546.6

p.P190delins

c.568_569delinsTT

1 paper

NM_000546.6

p.A189delFs

c.565_566delGC

3 papers

NM_000546.6

p.P190insFs

c.569dupC

18 papers

NM_000546.6

p.P190fs

c.568_569fs