Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

109 papers

NM_000546.6

p.R175P

c.524G>C

Surrounding Variants

140 papers

NM_000546.6

p.R175L

c.524G>T

NM_001276760.3

p.R136L

c.407G>T

3564 papers

NM_000546.6

p.R175H

c.524G>A

NM_001126115.2

p.R43H

c.128G>A

NM_001126118.2

p.R136H

c.407G>A

1 paper

NM_000546.6

p.R175delFs

c.523delG

1 paper

NM_000546.6

p.Q165_R174del10

c.493_521del30

158 papers

NM_000546.6

p.R175C

c.523C>T

149 papers

NM_000546.6

p.R175G

c.523C>G

1 paper

NM_000546.6

p.R175R

c.525C>G

1 paper

NM_000546.6

p.R175insFs

c.523_524insG

1 paper

NM_000546.6

p.V172_R174insFs

c.515_522dup8

2 papers

NM_000546.6

p.R175insFs

c.523_524ins4

13 papers

NM_000546.6

p.R175fs

c.523_524fs

20 papers

NM_000546.6

p.R175S

c.523C>A