Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

20 papers

NM_000546.6

p.R175S

c.523C>A

Surrounding Variants

158 papers

NM_000546.6

p.R175C

c.523C>T

149 papers

NM_000546.6

p.R175G

c.523C>G

1 paper

NM_000546.6

p.R175insFs

c.523_524insG

1 paper

NM_000546.6

p.V172_R174insFs

c.515_522dup8

2 papers

NM_000546.6

p.R175insFs

c.523_524ins4

2 papers

NM_000546.6

p.R174delFs

c.521delC

1 paper

NM_000546.6

p.R174del1

c.520_521delCCT

1 paper

NM_000546.6

p.V172_R174del0

c.514_522del9

4 papers

NM_000546.6

p.R175fs

c.523_524fs

140 papers

NM_000546.6

p.R175L

c.524G>T

NM_001276760.3

p.R136L

c.407G>T

14 papers

NM_000546.6

p.R174S

c.522G>T

1 paper

NM_000546.6

p.R174_R175insFs

c.522_523insCG