Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

32 papers

NM_000546.6

p.R174K

c.521G>A

NM_001126118.2

p.R135K

c.404G>A

Surrounding Variants

4 papers

NM_000546.6

p.R174M

c.521G>T

1 paper

NM_000546.6

p.R174insFs

c.521_522insCG

3 papers

NM_000546.6

p.R174T

c.521G>C

1 paper

NM_000546.6

p.T170_V173del4

c.508_518del12

14 papers

NM_000546.6

p.R174S

c.522G>T

1 paper

NM_000546.6

p.R174_R175insFs

c.522_523insCG

13 papers

NM_000546.6

p.R174fs

c.520_521fs

14 papers

NM_000546.6

p.R174S

c.522G>C

1 paper

NM_000546.6

p.R174R

c.522G>A

12 papers

NM_000546.6

p.R174fs

c.520_521fs

1 paper

NM_000546.6

p.Q165_R174delFs

c.493_521del29

64 papers

NM_000546.6

p.R174W

c.520A>T