Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

73 papers

NM_000546.6

p.K139N

c.417G>T

Surrounding Variants

1 paper

NM_000546.6

p.K139_T140insFs

c.417_418insT

1 paper

NM_000546.6

p.K139_T140insFs

c.417_418insC

21 papers

NM_000546.6

p.K139fs

c.415_416fs

1 paper

NM_000546.6

p.K139insFs

c.416dupA

71 papers

NM_000546.6

p.K139N

c.417G>C

4 papers

NM_000546.6

p.K139K

c.417G>A

6 papers

NM_000546.6

p.K139delFs

c.416delT

1 paper

NM_000546.6

p.K139delins

c.416_417delinsGC

1 paper

NM_000546.6

p.K139delins

c.416_417delinsTA

1 paper

NM_000546.6

p.K139delFs

c.415_416delTT

1 paper

NM_000546.6

p.K139delins

c.415_417delinsTTC

1 paper

NM_000546.6

p.K139delins

c.415_417delinsTGC