Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q136delins

c.406_407delinsTC

Surrounding Variants

9 papers

NM_000546.6

p.Q136L

c.407A>T

15 papers

NM_000546.6

p.Q136R

c.407A>G

43 papers

NM_000546.6

p.Q136P

c.407A>C

1 paper

NM_000546.6

p.Q136insFs

c.407_408insT

1 paper

NM_000546.6

p.Q136insFs

c.407_408insG

12 papers

NM_000546.6

p.Q136insFs

c.406_407insC

1 paper

NM_000546.6

p.F134_Q136ins1

c.401_406dup6

1 paper

NM_000546.6

p.L130_Q136insFs

c.388_406dup19

1 paper

NM_000546.6

p.Q136delins

c.406_407delinsGT

1 paper

NM_000546.6

p.Q136delins

c.406_407delinsAT

1 paper

NM_000546.6

p.Q136delins

c.406_407delinsGG

1 paper

NM_000546.6

p.Q136delins

c.406_407delinsGC