Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

52 papers

NM_000546.6

p.Y126H

c.376T>C

Surrounding Variants

1 paper

NM_000546.6

p.Y126insFs

c.376_377insG

1 paper

NM_000546.6

p.Y126insFs

c.376_377insC

78 papers

NM_000546.6

p.Y126D

c.376T>G

46 papers

NM_000546.6

p.Y126N

c.376T>A

5 papers

NM_000546.6

p.Y126fs

c.376_377fs

35 papers

NM_000546.6

p.T125_Y126Splc

c.376-1G>T

20 papers

NM_000546.6

p.T125_Y126Splc

c.376-1G>C

131 papers

NM_000546.6

p.T125_Y126Splc

c.376-1G>A

9 papers

NM_000546.6

p.Y126F

c.377A>T

163 papers

NM_000546.6

p.Y126C

c.377A>G

27 papers

NM_000546.6

p.Y126S

c.377A>C

1 paper

NM_000546.6

p.Y126insFs

c.377_378insT