Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S46Fs

c.137delinsGTFs

Surrounding Variants

36 papers

NM_000546.6

p.S46F

c.137C>T

NM_001126118.2

p.S7F

c.20C>T

8 papers

NM_000546.6

p.S46C

c.137C>G

8 papers

NM_000546.6

p.S46Y

c.137C>A

1 paper

NM_000546.6

p.L45_S46insFs

c.135_136insGA

55 papers

NM_000546.6

p.S46A

c.136T>G

17 papers

NM_000546.6

p.S46P

c.136T>C

7 papers

NM_000546.6

p.S46T

c.136T>A

1 paper

NM_000546.6

p.L45delFs

c.135delC

1 paper

NM_000546.6

p.M44_L45del1

c.132_134delAGC

1 paper

NM_000546.6

p.S46S

c.138C>T

1 paper

NM_000546.6

p.S46S

c.138C>G

6 papers

NM_000546.6

p.S46fs

c.136_137fs