Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M44_L45del1

c.132_134delAGC

Surrounding Variants

1 paper

NM_000546.6

p.L45_S46insFs

c.135_136insGA

55 papers

NM_000546.6

p.S46A

c.136T>G

17 papers

NM_000546.6

p.S46P

c.136T>C

7 papers

NM_000546.6

p.S46T

c.136T>A

1 paper

NM_000546.6

p.L45delFs

c.135delC

4 papers

NM_000546.6

p.S46fs

c.136_137fs

3 papers

NM_000546.6

p.L45insFs

c.134_135insT

2 papers

NM_000546.6

p.L45fs

c.133_134fs

6 papers

NM_000546.6

p.L45L

c.135G>C

3 papers

NM_000546.6

p.L45L

c.135G>A

1 paper

NM_000546.6

p.L45delFs

c.133_134delAG

1 paper

NM_000546.6

p.M44_L45delFs

c.131_134del4