Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.S33T

c.97T>A

Surrounding Variants

1 paper

NM_000546.6

p.S33insFs

c.97_98insC

1 paper

NM_000546.6

p.S33_P34ins6

c.97_101ins18

31 papers

NM_000546.6

p.S33A

c.97T>G

15 papers

NM_000546.6

p.S33P

c.97T>C

6 papers

NM_000546.6

p.S33fs

c.97_98fs

14 papers

NM_000546.6

p.L32_S33Splc

c.97-1G>T

18 papers

NM_000546.6

p.L32_S33Splc

c.97-1G>C

33 papers

NM_000546.6

p.L32_S33Splc

c.97-1G>A

21 papers

NM_000546.6

p.S33F

c.98C>T

63 papers

NM_000546.6

p.S33C

c.98C>G

4 papers

NM_000546.6

p.S33insFs

c.97dupT

1 paper

NM_000546.6

p.S33insFs

c.98_99insG