Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.L26fs

c.76_77fs

Surrounding Variants

13 papers

NM_000546.6

p.L26F

c.76C>T

11 papers

NM_000546.6

p.L26V

c.76C>G

1 paper

NM_000546.6

p.L26_P27insGGT

c.76_80ins9

15 papers

NM_000546.6

p.L26I

c.76C>A

1 paper

NM_000546.6

p.L26insFs

c.76dupC

10 papers

NM_000546.6

p.L26R

c.77T>G

16 papers

NM_000546.6

p.L26P

c.77T>C

8 papers

NM_000546.6

p.L26H

c.77T>A

2 papers

NM_000546.6

p.L26delFs

c.76delG

2 papers

NM_000546.6

p.L25L

c.75A>T

11 papers

NM_000546.6

p.L25L

c.75A>G

9 papers

NM_000546.6

p.L25L

c.75A>C