Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.L25L

c.75A>G

Surrounding Variants

2 papers

NM_000546.6

p.L25L

c.75A>T

9 papers

NM_000546.6

p.L25L

c.75A>C

8 papers

NM_000546.6

p.L25R

c.74T>G

9 papers

NM_000546.6

p.L25P

c.74T>C

45 papers

NM_000546.6

p.L25Q

c.74T>A

3 papers

NM_000546.6

p.L26fs

c.76_77fs

5 papers

NM_000546.6

p.L25Splc

c.75-1G>T

6 papers

NM_000546.6

p.L25Splc

c.75-1G>C

10 papers

NM_000546.6

p.L25Splc

c.75-1G>A

13 papers

NM_000546.6

p.L26F

c.76C>T

11 papers

NM_000546.6

p.L26V

c.76C>G

1 paper

NM_000546.6

p.L26_P27insGGT

c.76_80ins9