Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.S20T

c.58T>A

Surrounding Variants

1 paper

NM_000546.6

p.S20insFs

c.58_59insA

9 papers

NM_000546.6

p.S20A

c.58T>G

7 papers

NM_000546.6

p.S20P

c.58T>C

2 papers

NM_000546.6

p.T18_F19del2

c.52_56del6

1 paper

NM_000546.6

p.Q16_F19del0

c.46_57del12

1 paper

NM_000546.6

p.P4_F19del16

c.10_56del48

4 papers

NM_000546.6

p.S20fs

c.58_59fs

1 paper

NM_000546.6

p.F19_S20insFs

c.57_58insG

1 paper

NM_000546.6

p.F19_S20ins2

c.57_58ins6

9 papers

NM_000546.6

p.F19L

c.57T>G

3 papers

NM_000546.6

p.F19F

c.57T>C

9 papers

NM_000546.6

p.F19L

c.57T>A