Varaico: Literature-Extracted Genetic Variants

WNK1

951 papers

RefSeq Summary

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride io...

Pfam Domains

Pkinaseaa 221–479UCSCProtein kinase domain

OSR1_Caa 500–563UCSCOxidative-stress-responsive kinase 1 C-terminal domain

CCTL2_WNKaa 870–947UCSCWNK CCTL2 domain

CCTL2_WNKaa 1117–1194UCSCWNK CCTL2 domain

Gene Aliases

HGNC Name

WNK lysine deficient protein kinase 1

HGNC Previous Symbols

PRKWNK1; HSN2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_018979.4

p.A377S

c.1129G>T

Surrounding Variants

3 papers

NM_018979.4

p.S378A

c.1132T>G

6 papers

NM_018979.4

p.F379insFs

c.1135_1136insT

1 paper

NM_018979.4

p.K375*

c.1123A>T

1 paper

NM_018979.4

p.A372T

c.1114G>A

1 paper

NM_018979.4

p.A372P

c.1114G>C

1 paper

NM_018979.4

p.A372S

c.1114G>T

7 papers

NM_018979.4

p.L369F

c.1105C>T

17 papers

NM_018979.4

p.D368A

c.1103A>C

1 paper

NM_018979.4

p.G385Splc

c.1153+2T>C

1 paper

NM_018979.4

p.D368N

c.1102G>A

4 papers

NM_018979.4

p.S363_V364insFs

c.1089_1090insT

1 paper

NM_018979.4

p.S363P

c.1087T>C